Feline Syncytium-forming Virus: DNA Provirus Size and Structure
نویسندگان
چکیده
منابع مشابه
McDonough feline sarcoma virus: characterization of the molecularly cloned provirus and its feline oncogene (v-fms).
The genetic structure of the McDonough strain of feline sarcoma virus (SM-FeSV) was deduced by analysis of molecularly cloned, transforming proviral DNA. The 8.2-kilobase pair SM-FeSV provirus is longer than those of other feline sarcoma viruses and contains a transforming gene (v-fms) flanked by sequences derived from feline leukemia virus. The order of genes with respect to viral RNA is 5'-ga...
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Studies of feline leukemia virus (FeLV) have illustrated the importance of the genotype of the infecting virus in determining disease outcome. In FeLV infections, as in other retroviral infections, it is less clear how virus variants that evolve from the transmitted virus affect pathogenesis. We previously reported an analysis of the genotypic changes that occur in the viral envelope gene (env)...
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Ophthalmic manifestations of FeLV or FIV infection can occur in all ocular tissues and may be manifestations of direct viral effects or secondary to viral-related malignant transformation. Additionally, the manifestations of common feline ophthalmic pathogens may be more severe and poorly responsive to therapy because of the immunosuppressive effects of FeLV or FIV infection. Prompt diagnosis o...
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I have discussed the observations and experiments that led to the formulation and establishment of the provirus hypothesis and the DNA provirus hypothesis, which includes RNA-directed DNA synthesis for the formation of the provirus. I have also discussed some aspects of the present status of our knowledge of the mechanism of formation of the DNA provirus both to point out the work remaining to ...
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The effect of productive murine leukemia virus (MuLV) infection of the syncytium-forming property of XC cells was studied MuLV-Moloney-infected XC cells, designated XC(M), initially went through a period of spontaneous syncytium formation. The syncytia then disappeared, and XC(M) cells continued to propagate and produce both infectious MuLV and MuLV group-specific antigens. However, XC(M) cells...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1979
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-44-1-145